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Because the search for safe and effective chemotherapeutic agents has been hindered by antimicrobial resistance and toxic harm, there is a growing need to understand how the immune system can be manipulated to control infections, particularly HIV. In Immunotherapy for Infectious Diseases, Jeffrey M. Jacobson, md, and a group of leading researchers active in the field review the state-of-the-art for treating various infections-particularly HIV-by manipulating the immune system's response rather than by using chemical drugs. The contributors synthesize the principles of immune defense on the molecular level (monoclonal antibodies, vaccines, methods of antigen presentation, and cytokines and cytokine antagonists), as well as on the cellular and clinical levels as a protection against infection. The review of the current state of anti-HIV immunotherapy covers HIV-specific passive and active immunization strategies, gene therapy, and host cell-targeted approaches for treating HIV infection and restoring immune function. Also discussed are immunotherapy for other viral infections, virus-associated malignancies, bacterial infections and sepsis, tuberculosis, and fungal infections.
Comprehensive and cutting-edge, Immunotherapy for Infectious Diseases reviews all the current state-of-the-art developments occurring in this rapidly evolving field and helps set the stage for the early development of better immunologically based therapies for infections.
Sommario
I Basic Principles of Immunity.- 1 Humoral Immunity.- 2 Some Basic Cellular Immunology Principles Applied to the Pathogenesis of Infectious Diseases.- 3 Immune Defense at Mucosal Surfaces.- II Molecular Basis for Immunotherapy.- 4 Production of Immunoglobulins and Monoclonal Antibodies Targeting Infectious Diseases.- 5 Dendritic Cells: Their Role in the Immune Response to Infectious Organisms and Their Potential Use in Therapeutic Vaccination.- 6 Cytokines, Cytokine Antagonists, and Growth Factors for Treating Infections.- 7 Principles of Vaccine Development.- III Immunotherapy for HIV Infection.- 8 Immunopathogenesis of HIV Infection.- 9 Immune Reconstitution with Antiretroviral Chemotherapy.- 10 Active Immunization as Therapy for HIV Infection.- 11 Passive Immunotherapy for HIV Infection.- 12 Host Cell-Directed Approaches for Treating HIV and Restoring Immune Function.- 13 Gene Therapy for HIV-1 Infection.- IV Immunotherapy for Infectious Diseases Other than H.- 14 Immunotherapy for Viral Infections Other than HIV.- 15 Immunotherapy for Virus-Associated Malignancies.- 16 Immunotherapy of Bacterial Infections and Sepsis.- 17 Immunotherapy for Tuberculosis and Other Mycobacterial Infections.- 18 Immunotherapy for Fungal Infections.
Riassunto
In Immunotherapy for Infectious Disease, Jeffrey M. Jacobson, MD, and a panel of leading researchers review the state-of-the-art for treating various infections-particularly HIV-by manipulating the immune system's response rather than by chemical drugs. The contributors synthesize the principles of immune defense on the molecular level (monoclonal antibodies, vaccines, methods of antigen presentation, and cytokines and cytokine antagonists), as well as on the cellular and clinical levels levels as a protection against infection. The review of the current state of anti-HIV immunotherapy covers HIV-specific passive and active immunization strategies, gene therapy, and host cell-targeted approaches for treating HIV infection and restoring immune function.
Testo aggiuntivo
"This book is extemely well-organiaed, and while it conains alot of new information, it is easy to read due to its presentation. Thus, while each chapter could stand alone, the way in which the information is integrated enhances its clarity as the format melds the old information with the new. Finally, the topic is timely and comprehensive." -Doody's Health Sciences Book Review Journal
Relazione
"This book is extemely well-organiaed, and while it conains alot of new information, it is easy to read due to its presentation. Thus, while each chapter could stand alone, the way in which the information is integrated enhances its clarity as the format melds the old information with the new. Finally, the topic is timely and comprehensive." -Doody's Health Sciences Book Review Journal
