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Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on "Protein Kinases" related pathways that threaten human health and life. As "Protein Kinases" are related to many health problems, clinicians, basic science researchers and students need this information.
Chapter "Signal Transduction in Immune Cells and Protein Kinases" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Sommario
Protein kinase-mediated decision between life and death.- Aging, cellular senescence and protein kinases.- Oxidative stress-related endothelial cell death and protein kinases .- Signal transduction in immune cells and protein kinases.- Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity.- Metabolic stress and immunity.- Activation of tropomyosin-related kinase receptor B by N-acetyl-serotonin: implications for neuroprotection.- Protein kinase inhibitors in traumatic brain injury and repair .- Amyloid beta toxicity in Alzheimer's Disease and neuronal death-associated protein kinases.- Glucolipotoxicity-related beta cell death and protein kinases .- Protein kinases and cell death in hematological disorders.- A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy.- Bile acid toxicity andprotein kinases.- Nanoparticle toxicity: Protein kinases and cell death.- Two-component signal transduction systems in antibiotic resistance.- ERK1/2 MAP kinase, its regulation and role in cellular activities including apoptosis and cell survival.
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Ayse Basak ENGIN, M.Sc., Ph.D., Ph.D., E.R.T., ATS received her undergraduate degree in Pharmacy and MSc. degree in Toxicology from Hacettepe University. She completed her PhD studies in Toxicology and Immunology at Gazi University. She is currently working at the same University, Faculty of Pharmacy, Department of Toxicology as a full professor. Dr. Engin authored/co-authored several publications, book chapters and edited 4 books. She has been awarded Blair-Curtius-Pfleiderer-Wachter Award for Pteridine Research and Turkish Pharmaceutical Science Academy Young Scientist Award. Her work is mainly focused on pteridines and tryptophan metabolism-neurotoxicology, immunotoxicology and nanosafety-nanomedicine.
Atilla ENGIN M.D., Ph.D. was formerly Professor of General Surgery at Gazi University. He is currently professor emeritus. He earned Ph.D. in Biochemistry from Hacettepe University. His doctoral research led to discovery of the relationship betweenthe cancer growth-rate and tissue glutathione concentrations, and these works have been cited for several times and won the "Science Award in Surgery". He is a pioneer scientist in experimental surgery. His nationally and internationally funded research projects' findings, book chapters and edited 7 books have been cited in numerous international publications. While some of these outcomes received national and international awards, some of them were included into scientific databases. His work is mainly focused on oxidative stress, endocrine and metabolic pathways.
