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Sommario
1. Pharmacokinetic-Pharmacodynamic Modeling of Reversible Drug Effects 2. Pharmacokinetic-Pharmacodynamic Modeling of Irreversible Drug Effects 3. Pharmacokinetic-Pharmacodynamic Modeling in Drug Development: Comments and Applications 4. Dose Optimization Based on Pharmacokinetic-Pharmacodynamic Modeling 5. Pharmacokinetic-Pharmacodynamic Correlations of Anesthetics Agents 6. Pharmacokinetic-Pharmacodynamic Correlations of Analgesics 7. Pharmacokinetic-Pharmacodynamic Correlations of Benzodiazepines 8. Pharmacokinetic-Pharmacodynamic Correlations of Anticonvulsants 9. Pharmacokinetic-Pharmacodynamic Correlations of Cardiovascular Drugs 10. Pharmacokinetic-Pharmacodynamic Correlations of Selected Vasodilators 11. Pharmacodynamics Correlations of Anticoagulants 12. Pharmacokinetic-Pharmacodynamic Correlations of Antihistamines 13. B2-Agonists: Terbutaline, Albuterol, and Fenoterol 14. Pharmacokinetic-Pharmacodynamic Correlations of Corticosteriods 15. Pharmacokinetic-Pharmacodynamic Modeling of Antibiotics 16. Clinical Pharmacodynamics of Anticancer Drugs 17. Computer Applications in Clinical Pharmacokinetics and Pharmacodynamics
Info autore
Hartmut Derendorf, Ph.D., is Professor and Chairman of the Department of Pharmaceutics in the College of Pharmacy, University of Florida in Gainesville, Florida.
Gunther Hochhaus, Ph.D., is Associate Professor of the Department of Pharmaceutics in the College of Pharmacy, University of Florida in Gainesville, Florida.
Riassunto
First published in 1995: Combining the established disciplines of pharmacokinetics (PK), the relationship between drug concentration and time, and pharmacodynamics (PD), the relationship between drug effects and concentration, this handbook examines the relevant relationship between drug effects and time.
