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The landmark description by Delay and Deniker in 1952 of chlorpromazine's effect in psychosis suddenly eclipsed all other progress in psychopharmacology over the previous centuries. Since this report 35 years ago, a vast amount of research has contributed to the major advances in treatment that have improved the lives of millions of patients who would otherwise be incapacitated by their psychiatric disorders. This research has also led to valuable new insights into the causes of mental illnesses and the mechanisms of action of therapeutic drugs. However, there is much more work to be done. Thus, it is of great value periodically to assess the present state of knowledge as a first step to charting future directions. This symposium held in Denmark in 1987 covered many critical issues in psychopharmacology. The etiology, pathogenetic mechanisms, clinical aspects, and future directions of research in schizophrenia, affective disorders, anxiety, and dementia are addressed. Several of the problems with current therapeutic agents, such as side effects and limited efficacy, are also reviewed. Preclinical strategies with existing and new animal and computer models are discussed to point the way for developing better psychopharmacologic treatments of all psychiatric disorders.
Sommario
Schizophrenia.- Reflections on the History of Psychopharmacology.- Receptor Interactions of Dopamine and Serotonin Antagonists: Binding In Vitro and In Vivo and Receptor Regulation.- PET Scanning - A New Tool in Clinical Psychopharmacology.- Pharmacokinetics of Neuroleptic Drugs and the Utility of Plasma Level Monitoring.- Neuroleptic Drugs in the Treatment of Acute Psychosis: How Much Do We Really Know?.- Observations on the Use of Depot Neuroleptics in Schizophrenia.- Neuroleptic Side Effects: Acute Extrapyramidal Syndromes and Tardive Dyskinesia.- Future Treatment of Schizophrenia.- A Clinician's Comments on Current Trends in Psychopharmacology of Schizophrenia.- Affective Disorders.- Treating Depression in Acute Stage: Biochemical and Clinical Aspects.- Pharmacological Management of Treatment-Resistant Depression.- Is There a Long-Term Protective Effect of Mood-Altering Agents in Unipolar Depressive Disorder?.- Lithium in Manic-Depressive Illness: Plusses, Pitfalls, and Perspectives.- Basic and Clinical Aspects of the Activity of the New Monoamine Oxidase Inhibitors.- Unsolved Problems in the Pharmacotherapy of Depression.- Anxiety, Dementia, and Other Special Topics.- Long-Term Treatment of Anxiety: Benefits and Drawbacks.- Future Directions in Anxiety Research.- Dementia: Classification and Aspects of Treatment.- Test Models and New Directions in Dementia Research.- On Current Research in Affective Disorders.
