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This volume provides a comprehensive account of the mostrecent trends in human leukemia, as presented at the NinthWilsede Meeting. The internationally renowned contributorsdeal with all different aspects of these diseases: As wellas discussing important clinical aspects of leukemia, newinformation on the biological basis of leukemia gained usingthe methods of molecular genetics, cell and molecularbiology, virology, and immunology is covered. The book showsboth the complexity of leukemia research, as well as thevalue of basic scientific research in furthering clinicalmedicine and therapy.
Sommario
Clinical Aspects.- Bone Marrow Transplantation in Children with Acute Leukemia: A 1990 View.- Proliferation-Including Effects of Recombinant Human Interleukin-7 and Interleukin-3 in B-Lineage Acute Lymphoblastic Leukemia.- Effects of Granulocyte Colony-Stimulating Factor in Children with Severe Congenital Neutropenia.- Interleukin-1 Production in Patients with Nonlymphocytic Leukemia and Myelodysplastic Syndromes.- The Results of Treatment of Acute Lymphoblastic Leukemia Relapses in the Polish Children's Leukemia/Lymphoma Study Group.- Long-Term Follow-up Study in Childhood Acute Lymphoblastic Leukemias.- Monoclonal Blast Cell Proliferation in Transient Myeloproliferative Disorder.- The Comparison of the Expression of Activation Antigens on Peripheral Blood Mononuclear Cells in Chronic Lymphocytic Leukemia and in Hairy Cell Leukemia.- Multiple Myeloma: Immunodeficient, Osteolytic, Renal, and Amyloid Syndromes.- Prognostic Factors in Patients with Multiple Myeloma.- Cytogenetic Disorders During Tumor Progression in Leukemia.- New Cytogenetic Aspects of Myelodysplasia and Acute Leukemia.- Detection of Minimal Residual Leukemia by Polymerase Chain Reactions.- Structural Changes in Blast Cell Chromatin and DNA in Patients with Acute Leukemia After Cytosar and Irradiation Treatment.- Cell Biology.- Animal Models of Normal and Leukemic Human Hematopoiesis.- Colony Stimulating Factors: Regulation of Production.- Adhesive Interactions in the Regulation of Haemopoiesis.- In Vitro Effect of GM-CSF and IFN-? on the Establishment of Stromal Layer and Hemopoiesis in Human Dexter Culture.- The Effect of Bone Marrow Fibroblast and Stromal Cell-Conditioned Media on Hemopoietic Cells in Culture.- Hemopoietic Stem Cells in Embryogenesis of the Mouse.- Induction of Differentiation ofthe Human Promyelocytic Cell Line (HL-60) by Conditioned Medium of Ceathea letifera-Stimulated Mononuclear Cells.- Molecular Mechanisms in Myeloid Lineage Development.- Proteoglycans in Cellular Recognition and Secretory Functions in the Haemopoietic System.- Modification of the In Vitro Replication of the Human Immunodeficiency Virus HIV-1 by TPSg, a Polysaccharide Fraction Isolated from the Cupressaceae Thuja occidentalis L. (Arborvitae).- Molecular Genetics.- Molecular Cloning and Expression of CD 34: A Haemopoietic Progenitor-Associated Cell Surface Glycoprotein.- Molecular Genetics of the Human GM-CSF Receptor.- Structural Organization of the Cytokine Gene Cluster on Human Chromosome 5.- Genes Encoding Tumor Necrosis Factors: Genome Organization, Polymorphism, and Expression.- Molecular Characterization of the Mouse Interleukin-3 Receptor.- Signal Transduction Through Foreign Growth Factor Receptors and Oncogenes Transfected into Interleukin-3-Dependent Hematopoietic Cells.- Genetic Analysis of Ion Transport.- Virology.- The Molecular Biology of the Myeloproliferative Leukemia Virus.- Raf Function is Required for Proliferation of NIH/3T3 Cells and Transformation by Nonnuclear Oncogenes.- erbB*a: an "Ignition Spark" for the Xiphorus Melanoma Machinery?.- Analysis of Human Retroviral Regulatory Proteins Tax and Tat.- Human Neuroblastoma: Paradigm for a Tumor with Oncogene Amplification and Loss of a Putative Tumor Suppressor Gene.- Activation of Gene Expression by Human Herpes Virus 6.- Expression of S71-Related Sequences in Human Cells.- Selective Integration of Rous Sarcoma Virus Genome in High- and Low-Metastatic Transformed Cell Lines.- Molecular Mechanism of Alteration of H-ras I Oncogene in Human Breast Carcinomas: G to T Transversion in 12th Codon of theUndeleted Allele in the Case of the Loss of the Other Gene Allele.- Immunology.- Natural Killer Cell Mediated Defence Directed Selectively Against Target Cells Lacking MHC Class I Gene Products.- Tumor Rejection Antigens and Immune Surveillance.- Glycophosphatidylinositol-Anchored Membrane Proteins as Coreceptors in T-Cell Activation.- The Molecular Mechanism of Muramyl Peptides' Biological Activity.- A Nove
