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Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.
Table des matières
Preface
Vladimir N. Uversky
1. Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis
Pushpendra Mani Mishra, Navneet C Verma, Chethana Rao, Vladimir N Uversky and Chayan K Nandi
2. Transient knots in intrinsically disordered proteins and neurodegeneration
Marek Cieplak, Mateusz Chwastyk, Lukasz Mioduszewski and Belisa R. H. de Aquino
3. IDPs and their complexes in GPCR and nuclear receptor signaling
Myriam Guillien, Albane le Maire, Assia Mouhand, Pau Bernadó, William Bourguet, Jean-Louis Banères and Nathalie Sibille
4. Intrinsic disorder-based design of stable globular proteins
Galina S. Nagibina, Tatiana N. Melnik, Ksenia A. Glukhova, Vladimir N. Uversky and Bogdan S. Melnik
5. The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation
Chelsea J. Webber, Shuwen (Eric) Lei and Benjamin Wolozin
6. Context-dependent HOX transcription factor function in health and disease
Sarah E. Bondos, Gabriela Geraldo Mendes and Amanda Jons
7. Dancing while self-eating: Protein intrinsic disorder in autophagy
Hana Popelka
8. Intrinsic disorder in the nickel-dependent urease network
Barbara Zambelli, Luca Mazzei and Stefano Ciurli
9. Disorder and cysteines in proteins: A design for orchestration of conformational see-saw and modulatory functions
Anukool A. Bhopatkar, Vladimir N. Uversky and Vijayaraghavan Rangachari
A propos de l'auteur
Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, F.A.I.M.B.E., Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his PhD from Moscow Institute of Physics and Technology and D.Sc. from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences. Since 2010, Professor Uversky has worked at University of South Florida, where he works on various aspects of protein intrinsic disorder phenomenon and analysis of protein folding and misfolding processes. He has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He also servs as an editor in a number of scientific journals.
