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Vital to academic researchers, the medical field, and especially to biotech and pharmaceutical scientists, metabolomics is a rapidly expanding field that will provide a key link between functional biology (phenotypes) and the inner workings of cells in tissues or whole organisms. In The Handbook of Metabolomics, expert researchers provide readers with the current state of metabolomic development and the integration of metabolomics with transcriptomics and proteomics, illustrated by research efforts related to toxicology and pharmacology. The detailed contributions deal with topics ranging from sample preparation and considerations, both laboratory and clinical, analytical methodologies for metabolite and isotopomer profiling, metabolic flux modeling, database construction, and the integration of 'omics for systems biochemical understanding, amongst other topics.
Thorough and authoritative, The Handbook of Metabolomics serves as an ideal reference for all those who wish to further pursue this promising area of study.
Table des matières
Introduction to Metabolomics.- Considerations of Sample Preparation for Metabolomics Investigation.- Clinical Aspects of Metabolomics.- Structural Mass Spectrometry for Metabolomics.- Metabolomic Applications of Inductively Coupled Plasma- Mass Spectrometry (ICP-MS).- Principles of NMR for Applications in Metabolomics.- Novel NMR and MS Approaches to Metabolomics.- Metabolic Flux Analysis.- Introduction to Metabolic Control Analysis (MCA).- Application of Tracer-Based Metabolomics and Flux Analysis in Targeted Cancer Drug Design.- Non-Invasive Fluxomics in Mammals by Nuclear Magnetic Resonance Spectroscopy.- Compositional Analysis of Phospholipids by Mass Spectrometry and Phosphorus-31 Nuclear Magnetic Resonance Spectroscopy.- The HumanCyc Pathway-Genome Database and Pathway Tools Software as Tools for Imaging and Analyzing Metabolomics Data.- Metabolomics-Edited Transcriptomics Analysis (META).
Résumé
Vital to academic researchers, the medical field, and especially to biotech and pharmaceutical scientists, metabolomics is a rapidly expanding field that will provide a key link between functional biology (phenotypes) and the inner workings of cells in tissues or whole organisms.
