STAT Inhibitors in Cancer

This volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials.

Table des matières

STATs in Health and Disease.- STAT Proteins in Cancer.- Translating STAT Inhibitors from the Lab to the Clinic.- Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials.- STAT3 Inhibitors in Cancer: A Comprehensive Update.- Targeting Upstream Janus Kinases.- Inhibitors of Upstream Inducers of STAT Activation

A propos de l'auteur

Alister C. Ward is Foundation Professor/Director of Pre-Clinical Studies, School of Medicine, Deakin University, Geelong, Australia.

Résumé

This volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials.

Détails du produit

• Collaboration: Aliste C Ward (Editeur), Alister C Ward (Editeur), Alister C. Ward (Editeur)
• Edition: Springer, Berlin
• Langues: Anglais
• Format d'édition: Livre Relié
• Sortie: 01.01.2016
• EAN: 9783319429472
• ISBN: 978-3-31-942947-2
• Pages: 195
• Dimensions: 166 mm x 17 mm x 244 mm
• Poids: 420 g
• Illustrations: VII, 195 p. 11 illus. in color.
• Thèmes: Cancer Drug Discovery and Development; Cancer Drug Discovery and Development
• Catégories: Sciences naturelles, médecine, informatique, technique > Médecine > Spécialités non cliniques; B, Medicine, Cancer Research, Biomedical Research, Cancer Biology, transcription factors