Biochemistry of Pulmonary Emphysema

Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.

Table des matières

From the Contents: Pulmonary Emphysema: What's going on.- Elastin and the Lung.- An Introduction to the Endopeptidases.- Lung Proteinase and Emphysema.- Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes.- Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates.- Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances.- Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), A Major Proteinase Inhibitor in the Human Lung.- Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema.- Genetic Control of Human Alpha-1-Antitrypson and Hepatic Gene Therapy.- Neutrophils, Neutrophil Elastase and the Fragile Lung.

Détails du produit

• Collaboration: L. Casali (Editeur), L Casali et al (Editeur), C. Grassi (Editeur), M. Luisetti (Editeur), Travis (Editeur), J Travis (Editeur), J. Travis (Editeur)
• Edition: Springer, Berlin
• Langues: Anglais
• Format d'édition: Livre de poche
• Sortie: 08.05.2014
• EAN: 9781447137733
• ISBN: 978-1-4471-3773-3
• Pages: 200
• Poids: 387 g
• Illustrations: XV, 200 p. 13 illus.
• Thèmes: Current Topics in Rehabilitation; Current Topics in Rehabilitation
• Catégories: Littérature spécialisée > Psychologie, ésotérique, spiritualité, anthroposophie > Psychologie appliquée; Sciences humaines, art, musique > Psychologie > Psychologie appliquée; Sciences naturelles, médecine, informatique, technique > Médecine > Professions médicales