Transforming Growth Factor-Beta in Cancer Therapy, Volume II - Cancer Treatment and Therapy

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.

Table des matières

Transforming Growth Factor-? In Developing and Advanced Cancers.- Transforming Growth Factor-? Signaling in Pancreas Development and Pancreatic Disease.- Role of Transforming Growth Factor-? in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma.- TGF-?, Smads and Cervical Cancer.- TGF-? Signaling and Biglycan in Pancreatic Cancer.- TGF-? Signaling in Endometrial Cancer.- TGF-? Ligands, TGF-? Receptors, and Lung Cancer.- Role of TGF-? in Osteolytic Bone Metastases.- Hormonal Regulation of Transforming Growth Factor-? in Breast Cancer.- TGF-? and Progression of Esophageal Cancer.- TGF-? and HER2/ErbB2 and Breast Cancer Progression.- TGF-? Dependent T-Cell Regulation in Colitis and Colon Cancer.- Role of Transforming Growth Factor-? in the Kidney - Physiology and Pathology.- Perturbations of TGF-? Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis.- Transforming Growth Factor-? in Brain Functions and Dysfunctions.- Inhibition of TGF-? Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment.- Key Roles of TGF-? and Smad3 in Prostate Cancer.- Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-? Type I Receptor.- Transforming Growth Factor-? in Cancer Treatment and Therapy.- High-Throughput Screening of Protein Interaction Networks in the TGF? Interactome: Understanding the Signaling Mechanisms Driving Tumor Progression.- Tumor Suppressor and Pro-progression Roles for TGF-? in Breast Cancer.- Tumor Suppressors p53 and TGF? Converge to Regulate the Alpha-Fetoprotein Oncodevelopmental Tumor Marker.- TGF?: Roles in DNA Damage Responses.- The Rationale for and Effects of Targeting TGF-? for Glioma Therapy.- TumorSuppressor Functions of TGF?1 in T Cells.- Therapeutic Effects of Adenovirus-Mediated Gene Transfer of TGF-? Signal Antagonists on Undesirable Epithelial-Mesenchymal Transition and Neovascularization.- Role of TGF-? in Tumor Protection and Antitumor Immunity.- Regulation of Angiogenesis and Tumor Growth by Thrombospondin-1.- Cancer-Associated Fibroblasts and the Role of TGF-?.- Adoptive Transfer of Tumor Reactive TGF-? Insensitive CD8+ T-cells for Cancer Therapy.- DNA Methylation and Histone Deacetylation Inhibitors as Potential Therapeutic Agents for the Reconstitution of TGF-? Signaling in Breast Cancer.- Reactive Stroma and Evolution of Tumors: Integration of Transforming Growth Factor-?, Connective Tissue Growth Factor, and Fibroblast Growth Factor-2 Activities.- TGF-? Signaling and Vascular Morphogenesis.- Aberrant Transforming Growth Factor-? Signaling in Human Pancreatic Cancer: Translational Implications.- TGF-? and Stromal Influences Over Local Tumor Invasion.- TGF-? at the Crossroads Between Inflammation, Suppression and Cancer.- Development of Inhibitors of Transforming Growth Factor-? Signaling for Therapy.- Transforming Growth Factor-? (TGF-?) Signaling Inhibitors in Cancer Therapy.- Targeting TGF-? as a Strategy to Ameliorate Intestinal Side Effects of Radiation Therapy.- Targeting Transforming Growth Factor-? in Metastasis: In Vitro and In Vivo Mechanisms.- Targeted Downregulation of TGF-?2 with AP 12009 in Tumor Therapy.- Modulating TGF-? Receptor Signaling: A Novel Approach of Cancer Therapy.- Engineering TGF-? Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-? Action.- The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors inOncology.- Soluble Type II Transforming Growth Factor-? Receptor Inhibits Tumorigenesis by Augmenting Host Antitumor Immunity.- Reversal of EMT by Small-Molecule Inhibitors of TGF-? Type I and II Receptors: Implications for Carcinoma Treatment.- Soluble TGF-? Type III Receptor Suppresses Malignant Progression of Human Cancer Cells.- Targeting Smad-Dependent TGF-? Signaling with Peptide Aptamers.- Rationale for Anti-TGF-? Antibody Therapy in Oncology.

Résumé

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.

Texte suppl.

From the reviews:

"This volume … provide readers with a detailed account of the role of TGF-beta in the development of various cancers in numerous organs. … This will likely be of interest to those in the field as well as those who are new … . will be of interest to researchers at all levels. The book will likely attract new researchers and students interested in becoming engaged in new frontiers of cancer therapy. … This will be a great resource for researchers and clinicians … ." (James P Luyendyk, Doody’s Review Service, June, 2008)

Commentaire

From the reviews:

"This volume ... provide readers with a detailed account of the role of TGF-beta in the development of various cancers in numerous organs. ... This will likely be of interest to those in the field as well as those who are new ... . will be of interest to researchers at all levels. The book will likely attract new researchers and students interested in becoming engaged in new frontiers of cancer therapy. ... This will be a great resource for researchers and clinicians ... ." (James P Luyendyk, Doody's Review Service, June, 2008)

Détails du produit

• Collaboration: Soni B Jakowlew (Editeur), Sonia B Jakowlew (Editeur), Sonia B. Jakowlew (Editeur), C.-H. Heldin (Préface)
• Edition: Springer, Berlin
• Langues: Anglais
• Format d'édition: Livre de poche
• Sortie: 26.10.2010
• EAN: 9781617377365
• ISBN: 978-1-61737-736-5
• Pages: 786
• Dimensions: 178 mm x 43 mm x 254 mm
• Poids: 1497 g
• Illustrations: XXVI, 786 p. 164 illus., 4 illus. in color.
• Thèmes: Cancer Drug Discovery and Development; Cancer Drug Discovery & Develo; Cancer Drug Discovery & Develo; Cancer Drug Discovery and Development
• Catégories: Sciences naturelles, médecine, informatique, technique > Médecine > Spécialités cliniques; Pathologie, B, Medicine, Zellbiologie (Zytologie), Translation, Regulation, Pathology, INTERNAL MEDICINE, Oncology, Cancer Research, Cellular biology (cytology), Biomedical Research, Cell Biology, Cancer Biology, tissue, tumor growth, Tumorigenesis