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Zusatztext Lathers and colleagues have produced a colossal and astonishingly comprehensive tome on a little-appreciated subject: sudden death in epilepsy (SUDEP). All physicians who have treated patients with severe epilepsy have experienced the anguish of losing a young patient to this ill-defined syndrome. This book addresses all the issues--from the clinical to the basic! from the forensic to the bereavement. Every physician who treats epilepsy will do well to draw from the extraordinary compilation of data and expertise in this volume.-Roger J. Porter! MD! ScD! Adjunct Professor of Neurology! University of Pennsylvania! Philadelphia and Adjunct Professor of Pharmacology! USUHS! BethesdaThe book is a skilled amalgam of neuroscience! cardiology! and pharmacology! along with numerous illustrative case examples! and it will become much thumbed-through as it takes a place of prominence on this forensic pathologist's bookshelf.-Gregory J. Davis! MD! FCAP! University of Kentucky College of Medicine! State Medical Examiner! Kentucky! in Et Cetera. Informationen zum Autor Claire M. Lathers, Paul L. Schraeder, Michael Bungo, Jan E. Leestma Klappentext Epilepsy is one of the most prevalent neurological diseases in the world! and carries with it the risk of sudden death. Edited by four of the most eminent experts in the field! this volume captures the state of the art and science in the study of sudden unexpected death in epilepsy. Topics discussed include the history! diagnosis! phenomenology! mechanisms! genetics! animal models! pathology! physiology and even the social repercussions of this devastating phenomenon. Taken as a whole! the content acts as a roadmap to those who hope to someday fully understand and prevent this dramatic and tragic event. Zusammenfassung Epilepsy is one of the most prevalent neurological diseases in the world, and carries with it the risk of sudden death. This volume captures the state of the art and science in the study of sudden unexpected death in epilepsy. It discusses the history, diagnosis, phenomenology, mechanisms, genetics, animal models, pathology, and physiology. Inhaltsverzeichnis Forensics of Sudden Death. Neurocardiologic Mechanistic Risk Factors in Sudden Unexpected Death in Epilepsy. Forensic Considerations and Sudden Unexpected Death in Epilepsy. Omega-3 Fatty Acids in Sudden Unexpected Death in Epilepsy: Guardian of the Brain–Heart Connection. Unanswered Questions: SUDEP Studies Needed. Medullary Serotonergic Abnormalities in Sudden Infant Death Syndrome: Implications in SUDEP. Forensic Case Identification. Sudden Unexpected Death in Epilepsy: Future Research Directions. Forensic Postmortem Examination of Victims of Sudden Unexpected Death in Epilepsy. One-Year Postmortem Forensic Analysis of Deaths in Persons with Epilepsy. Drug Abuse and SUDEP. Cocaine-Induced Seizures, Arrhythmias, and Sudden Death. Risk Factors for Sudden Death in Epilepsy. EEG Findings in SUDEP. Severity of Seizures as a Forensic Risk and Case Reports. Intractable Epilepsy in the Setting of Malformations of Cortical Development as a Mechanism for SUDEP. Neurogenic Cardiac Arrhythmias. Stress and SUDEP. Genetics of Sudden Death in Epilepsy. Cardiac Channelopathies and Sudden Death. Sodium Channel Dysfunction Common Physiopathologic Mechanism Associated with Sudden Death ECG Abnormalities in Brugada Syndrome and Some Types of Epilepsy: Case Histories. Not Seizure but Syncope. Syncope, Seizures, and SUDEP: Case Histories. Sudden Death in Epilepsy: Relationship to the Sleep–Wake Circadian Cycle and Fractal Physiology. SUDEP: Medicolegal and Clinical Experiences. SUDEP Animal Models. MECHANISMS OF RISKS. Sudden Death: Animal Models to Study Nervous System Sites of Action for Disease and Pharmacological Intervention. Synaptic Plasticity of Autonomic Ganglia: Role of Chronic Stress and Implication in Cardiovascular Dise...
