Classical Hematology - Expert Clinical Review: Questions and Answers

Master Classical Hematology with Confidence
This fully revised second edition offers a comprehensive, clinically focused exploration of Classical Hematology through a clear and engaging Q&A format. Designed to support hematologists and oncologists in everyday decision-making, it provides practical, evidence-based answers to both common and complex clinical challenges.
Spanning the full breadth of the specialty, the book features 74 expertly authored chapters organized into ten well-structured sections, covering:

• Red cell disorders
• Hemostasis, bleeding and thrombosis
• Thrombosis and coagulopathy in medical and surgical settings
• Medications affecting thrombosis and bleeding
• White cell abnormalities

List of contents

Part 1 Red cell disorders.- 1. Evaluation of Anemia in Children and Adults.- 2. Iron Homeostasis.- 3. Diagnosis and Management of Iron Deficiency Anemia.- 4. Iron Overload: Diagnosis, Complications, and Management.- 5. Anemia of Inflammation.- 6. Megaloblastic and Nutritional Anemias.- 7. Extrinsic Hemolytic Anemias.- 8. Intrinsic Hemolytic Anemias: Non-Hemoglobinopathies.- 9. Sideroblastic Anemias.- 10. Porphyrias: Diagnosis and Management.- 11. Disorders of Hemoglobin Synthesis: Pathophysiology and Diagnostic Evaluation.- 12. Thalassemia: Management Issues.- 13. Sickle Cell Disease: Outpatient Management and Prevention of Complications.- 14. Sickle Cell Disease: Management of Complications.- 15. Paroxysmal Nocturnal Hemoglobinuria and Pure Red Blood Cell Aplasia.- Part 2 Hemostasis and Bleeding Disorders.- 16. Coagulation and Fibrinolysis Pathways.- 17. Diagnostic Tests for Platelet Disorders.- 18. Principles of laboratory tests for vWF and coagulation factor function and disorders.- 19. Von Willebrand Disease: Differential Diagnosis and Diagnostic Approach to Specific Subtypes.- 20. von Willebrand Disease: Management.- 21. Hemophilia A.- 22. Hemophilia B.- 23. Coagulation Factor Inhibitors.- 24. Gene Therapy in Bleeding Disorders.- 25. Hereditary Disorders of Fibrinogen.- 26. Rare Clotting Factor Deficiencies.- 27. Fibrinolysis System: Disturbances and Clinical Implications.- 28. Inherited Platelet Disorders: Diagnosis and Management.- 29. Immune Thrombocytopenia.- 30. Other Acquired Platelet Disorders.- Part 3 Thrombosis.- 31. Hereditary Thrombophilias: Pathophysiology, Interpretation and Indications for Testing.- 32. Antiphospholipid Antibodies and Syndrome.- 33. Heparin-Induced Thrombocytopenia (HIT): Diagnosis and Management.- 34. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.- 35. Unidentifiable Thrombophilia.- 36. Prevention of Venous Thromboembolism.- 37. Venous Thromboembolism: Management.- 38. Complications of Venous Thromboembolic Disease.- 39. Arterial Thromboembolism.- 40. Surgical and interventional treatment of acute venous thromboembolic disease.- Part 4 Coagulopathy in Systemic and Surgical Disorders.- 41. Hemostasis Disturbances in Acute Leukemias and Myelodysplastic Neoplasms.- 42. Bleeding and Thrombosis in a Cancer Patient.- 43. Coagulopathy in critically ill patients.- 44. Trauma-Induced Coagulopathy.- 45. Management of the Surgical Patient with Thrombotic and Bleeding Diathesis.- Part 5 Medications in Thrombosis and Bleeding Disorders.- 46. Antiplatelets.- 47. Anticoagulation Agents and Thrombolytics.- 48. Antifibrinolytics.- Part 6 White Cell Abnormalities.- 49. Duffy-Null Associated Neutrophil Count.- 50. Primary Immunodeficiency Disorders: Diagnosis and Management.- 51. Disorders of Phagocytic Function and Number: Diagnosis and Treatment.- 52. Inherited Bone Marrow Failure Syndromes: Diagnosis and Management.- 53. Immune Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria.- 54. Lysosomal Storage Disorders: Hematology Perspective.- 55. Hemophagocytic Lymphohistiocytosis: Diagnosis and Management Challenges.- 56. Nonmalignant Leukocyte Disorders.- 57. Eosinophilia.- 58. Cryoglobulins and Cryoglobulinemia.- 59. Castleman Disease with and without Viral Infection(s) and Rosai-Dorfman-Destombes Disease.- Part 7: Disturbances in HIV and SARS-CoV-19 Infections.- 60. Hematologic Complications of HIV-Infection.- 61. Antithrombotic Management in SARS-CoV-2 infection.- Part 8: Fertility, Women s and Neonatal Health Issues.- 62. Hematologic Changes and Special Issues in Pregnancy.- 63. Thrombosis and Bleeding in Pregnancy.- 64. Fertility and Pregnancy in Patients with Thalassemia.- 65. Pregnancy and fertility issues in women with sickle cell disease.- 66. Alloimmune Hemolytic Anemia of the Fetus and Newborn.- 67. Developmental Coagulopathies.- 68. Congenital Erythrocytosis.- Part 9 Transfusion Medicine.- 69. Pre-transfusion testing methods and implications.- 70.Transfusion of Red

About the author

Syed Ali Abutalib, MD
Director, Hematologic Malignancies, Bone Marrow Transplantation and Cellular Therapy
Department of Hematologic Malignancies, Bone Marrow Transplantation and Cellular Therapy 
Aurora St. Luke's Medical Center
2900 W. Oklahoma Ave.Milwaukee, WI 53215 
[e-mail]
Founder and First Co-Editor-in-Chief, Advances in Cell & Gene Therapy 
 
Jean M. Connors
Cancer Hematology Division
Dana-Farber Cancer Institute
Boston, Massachusetts, USA
[e-mail] 
 
Margaret V. Ragni
Professor of Medicine
Department of Medicine
University of Pittsburgh Medical Center
Pittsburgh
Pennsylvania USA

Summary

Master Classical Hematology with Confidence
This fully revised second edition offers a comprehensive, clinically focused exploration of Classical Hematology through a clear and engaging Q&A format. Designed to support hematologists and oncologists in everyday decision-making, it provides practical, evidence-based answers to both common and complex clinical challenges.

Spanning the full breadth of the specialty, the book features
74 expertly authored chapters
organized into
ten well-structured sections
, covering:

• Red cell disorders
• Hemostasis, bleeding and thrombosis
• Thrombosis and coagulopathy in medical and surgical settings
• Medications affecting thrombosis and bleeding
• White cell abnormalities
• Hematologic disturbances in HIV and SARS-CoV-19 infections
• Fertility, women’s and neonatal health
• Transfusion medicine
• Hematopoietic growth factors
• Blood smear interpretation

A hallmark of this volume is the opportunity it provides physicians to engage with well-reasoned perspectives on challenging hematologic issues. The result is a
practical, immediately applicable reference
that bridges knowledge and clinical practice.

Accessible, comprehensive, and up to date, this essential Q&A resource is invaluable for residents, fellows, house officers, and experienced practitioners alike—and an outstanding companion for those preparing for internal hematology examinations and board certification.

Product details

• Assisted by: Syed A. Abutalib (Editor), Jean M. Connors (Editor), Jean M Connors (Editor), Margaret V. Ragni (Editor), Margaret V Ragni (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Release: 20.04.2026
• EAN: 9783032138576
• ISBN: 978-3-0-3213857-6
• No. of pages: 1028
• Illustrations: III, 1028 p. 137 illus., 111 illus. in color.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Onkologie, Hematology, Oncology, bleeding, thrombosis, Benign hematology, hemostasis, Non-malignant Hematology