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Focusses on the excited triplet states within DNA and RNA with combined experimental and computational approaches.
List of contents
Chapter 1 Introduce of triplet excited state in DNA and RNA
1.1 Introduction of the significance of triplet excited state in nucleic acids
1.2 Triplet excited state studies in 1960-70s with low temperature spectroscopy
1.3 Breakthroughs of time-resolved spectroscopy techniques and progress of triplet excited state study of DNA/RNA in 1980-2000
1.4 Current Research frontiers (2000s-present)
1.5 Book Structure Overview
Chapter 2 Triplet excited state in canonical nucleobases and their derivatives
2.1 Study on the triplet excited states dynamics of canonical nucleobases by laser flash photolysis and femtosecond transient absorption spectroscopy
2.2 Study on Triplet Excited-State Dynamics of Thio- and Selenium-Substituted Nucleobases
2.3 Study on Triplet Excited State Dynamics of Nitrogen-substituted Nucleobases
Chapter 3 Decoding Triplet-State Dynamics in Epigenetically Modified DNA and RNA: Photophysical Mechanisms from Nucleobase Monomers to Duplex
3.1 Introduction
3.2 Formation of Triplet State in Epigenetically Modified Nucleobase Monomer
3.3 Uracil C5-modified Nucleobases
3.4 Adenine N6-Modified Nucleobases
3.5 Guanosine N7-Modified Nucleobases
3.6 Formation of Triplet State in Epigenetically Modified Dinucleotides and Single-stranded Oligomers
3.7 Formation of Triplet State in Epigenetically Modified DNA duplex
3.8 Conclusion
Chapter 4 Triplet-Mediated Photochemistry of Nucleic Acid Bases
4.1 Introduction
4.2 Photoaddition reactions
4.3 Photooxidation reactions
4.4 Photo-crosslinking reactions
4.5 Conclusions
Chapter 5 Drug-sensitized triplet states generation in DNA
5.1 Introduction
5.2 The triplet-triplet energy transfer process
5.3 The triplet energy of nucleobases
5.4 Structure and triplet excited state energies of the different nucleobases
5.5 Photoproducts arising from the nucleobase triplet excited state
5.6 Methodologies: Spectroscopic vs analytical techniques for detection of drug photosensitization of 3N*
5.7 Photosensitization of nucleobase triplet by drugs (or cosmetics)
5.8 Conclusion
Chapter 6 Triplet decay in canonical and noncanonical DNA/RNA nucleobases
6.1 Introduction
6.2 Low Triplet Yields in Natural DNA/RNA Nucleobases
6.3 Triplet State Decay in Thionucleobases
6.4 Theoretical and Computational Studies of Triplet Decay of Thionucleobases
6.5 Mechanisms of Chemical Modulation of Triplet Decay
6.6 Remaining Challenges and Future Directions
Chapter 7 Triplet state dynamics in DNA/RNA nucleobases and DNA by Ab initio static and surface-hopping dynamics simulations
7.1 Introduction
7.2 Adenine
7.3 Guanine
7.4 Uracil
7.5 Thymine
7.6 Cytosine
7.7 Non-natural nucleobases
7.8 Pyrimidine-pyrimidine dimer formation processes
7.9 Conclusions
Chapter 8 The photophysics and photochemistry of epigenetics and 'natural' non canonical bases: insights from quantum mechanical calculations.
8.1 Introduction
8.2 Epigenetic bases
8.3 Methylated purines
8.4 Concluding Remarks
About the author
Jinquan Chen, received his Ph.D. in physical chemistry at the Ohio State University in 2012. After postdoc experiences at Montana State University and Emory University, he joined East China Normal University in 2015, where he is now full professor. His main research interests involve the development of state of art femtosecond time-resolved spectroscopy techniques (such as femtosecond circular dichroism and circularly polarized luminescence spectroscopy) for the study of excited state dynamics of biomolecules. In the recent years, he focused in particular on the study of the photophysics and photochemistry of epigenetic nucleic acids and their triplet excited state dynamics. He has published over 130 journal articles. He is currently the Early Career Researcher Editorial Board member of Chinese Journal of Chemical Physics and vice president of the Shanghai Biophysics Society.
Summary
Focusses on the excited triplet states within DNA and RNA with combined experimental and computational approaches.
