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Informationen zum Autor Michael Fromm is the editor of Molecular Structure and Function of the Tight Junction: From Basic Mechanisms to Clinical Manifestations, Volume 1165, published by Wiley. Jörg-Dieter Schulzke is the editor of Molecular Structure and Function of the Tight Junction: From Basic Mechanisms to Clinical Manifestations, Volume 1165, published by Wiley. Klappentext Aim of this volume is to clarify the relationship between molecular structure and function of tight junction proteins, as well as their regulation and their role in diseases. Current research may form a basis for future diagnostic and therapeutic approaches to diseases which seem to have not much in common but are characterized by defects of organ barriers, like Crohn's disease, renal hypertension, inner ear deafness, and cancerous diseases.Topics include the functions of distinct tight junction proteins as barrier or channel formers for solutes and water, characteristics of the tight junction in inflammatory bowel diseases, posttranslational modifications of tight junction proteins, the relation between renal tight junction proteins and blood pressure control, and the molecular structure of claudin-claudin interactionsNOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member. Zusammenfassung Aim of this volume is to clarify the relationship between molecular structure and function of tight junction proteins, as well as their regulation and their role in diseases. Inhaltsverzeichnis Introduction. Tight junctions: Molecular structure meets function ( Jörg-Dieter Schulzke and Michael Fromm ). The Life and Work of Shoichiro Tsukita ( James Melvin Anderson ). Part I. Molecular Structure of the Tight Junction 1. Mechanisms of outside-in signaling at the tight junction by junctional adhesionmolecule A Eric A. Severson and Charles A. Parkos ). 2. The oligomerization of the coiled coil-domain of occluddin is redox-sensitive ( Juliane K. Walter, Christine Rueckert, Martin Voss, Sebastian L. Müller, Jörg Piontek, Klaus Gast and Ingolf E. Blasig ). 3. Vertebrate animal models unravel physiological roles for Zonula occludens tight junction adaptor proteins ( Walter Hunziker, Tania K. Kiener, and Jianliang Xu ). 4. Structure and function of extracellular claudin domains ( Gerd Krause, Lars Winkler, Christian Piehl, Ingolf Blasig, Jörg Piontek, Sebastian L. Müller ). 5. Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier function ( Sachiko Tsukita, Tatsuya Katsuno, Yuji Yamazaki, Kazuaki Umeda, Atsushi Tamura, and Shoichiro Tsukita ). 6. Molecular basis for cation selectivity in claudin-2-based pores ( Alan S. L. Yu ). 7. The role claudin-based tight junctions in morphogenesis ( Mikio Furuse ). 8. Occludin phosphorylation in regulation of epithelial tight junctions ( Radhakrishna Rao ). 9. Differential phosphorylation of occludin and tricellulin by CK2 and CK1 ( Max J. Dörfel, Julie K. Westphal and Otmar Huber ). Part II. Regulation of the Tight Junction and Barrier Function. 10. High resolution analysis of barrier function ( Michael Fromm, Susanne M. Krug, Sebastian Zeissig, Jan F. Richter, Rita Rosenthal, Jörg-Dieter Schulzke and Dorothee Günzel ). 11. Claudin-2-dependent changes in noncharged solute flux are mediated by...
