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Informationen zum Autor David Fredricks is an expert in infectious diseases and the human indigenous microbiota, with a research focus on the bacterial biota of the human vagina and how changes in the composition of vaginal microbes lead to the syndrome bacterial vaginosis. He has authored more than 32 peer reviewed journal articles, 7 book chapters, and 9 editorials or invited reviews. He has been a peer reviewer for more than a dozen major medical and infectious diseases journals, and has served on several NIH study sections. Klappentext Unraveling the mysteries of the human microbiomeAddressing the latest findings on the microbes that colonize epithelial surfaces in the human body, The Human Microbiota presents a comprehensive review of the microbial diversity found in humans and the role it plays in human health.After an introduction to the pivotal research efforts at the Human Microbiome Project, the book presents cutting-edge methods for studying the human microbiome and links particular microbial communities to various conditions and diseases. It explains in detail how to use animal models, cultivate microbes, and manipulate existing microbiota. Advice on the design of microbiome studies as well as the strengths and weaknesses of different methods is also included. A group of pioneers in microbial ecology contribute authoritative, state-of-the-art chapters on:* Characterization and analysis techniques as well as mathematical approaches for describing microbial communities* The different microbial populations found in the gut, the respiratory tract, the mouth, and the genital tract* Lessons learned from animal models about microbial communities and immune response to the microbiota* Novel approaches to cultivating human microbes in the laboratory, including their challenges and benefits* The use of prebiotics, probiotics, and synbiotics to enhance human healthThe Human Microbiota is an invaluable resource for microbiologists, microbial ecologists, physicians, infectious disease specialists, and anyone wishing to learn about the latest tools in molecular biology and what they reveal about this exciting, rapidly evolving field. "Having said that, I'm sure the book will be of interest to all those studying the effects of micro-organisms on the human body." ("Microbiology Today", 30 August 2013) Zusammenfassung * Provides a comprehensive description of the human microbiota * Incorporates the latest findings that have emerged from the use of tools in molecular microbiology * Includes perspectives and commentary by pioneers in human microbial ecology . Inhaltsverzeichnis PREFACE vii CONTRIBUTORS xi 1 THE NIH HUMAN MICROBIOME PROJECT 1 Lita M. Proctor, Shaila Chhibba, Jean McEwen, Jane Peterson, Chris Wellington, Carl Baker, Maria Giovanni, Pamela McInnes, and R. Dwayne Lunsford 2 METHODS FOR CHARACTERIZING MICROBIAL COMMUNITIES ASSOCIATED WITH THE HUMAN BODY 51 Christine Bassis, Vincent Young, and Thomas Schmidt 3 PHYLOARRAYS 75 Eoin L. Brodie and Susan V. Lynch 4 MATHEMATICAL APPROACHES FOR DESCRIBING MICROBIAL POPULATIONS: PRACTICE AND THEORY FOR EXTRAPOLATION OF RICH ENVIRONMENTS 85 Manuel E. Lladser and Rob Knight 5 TENSION AT THE BORDER: HOW HOST GENETICS AND THE ENTERIC MICROBIOTA CONSPIRE TO PROMOTE CROHN'S DISEASE 105 Daniel N. Frank and Ellen Li 6 THE HUMAN AIRWAY MICROBIOME 119 Edith T. Zemanick and J. Kirk Harris 7 MICROBIOTA OF THE MOUTH: A BLESSING OR A CURSE? 135 Angela H. Nobbs, David Dymock, and Howard F. Jenkinson 8 MICROBIOTA OF THE GENITOURINARY TRACT 167 Laura K. Sycuro and David N. Fredricks 9 FUNCTIONAL STRUCTURE OF INTESTINAL MICROBIOTA IN HEALTH AND DISEASE 211 Alexander Swidsinski and Vera Loening-Baucke 10...
