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This handbook is designed to provide readers with an unprecedented strategy approach to mechanism-guided process development, helping process chemists and students in industrial chemistry develop chemical processes efficiently. The latest edition addresses common process issues such as safety, cost, robustness, and environmental impact.
List of contents
1. Reaction solvent selection
2. Reagent selection
3. Various reagent surrogates
4. Modes of reagent addition -control of impurity formation
5. Process optimization with additives
6. Process optimization of catalytic reactions
7. Process optimization of problematic reactions
8. Hazards of oxidation and reduction reactions
9. Other hazardous reactions
10. Hazardous reagents
11. Grignard reagent and related reactions
12. Challenging reaction intermediates
13. Protecting groups
14. Telescope approach
15. Design of new synthetic route
16. Stereochemistry
17. Various quenching strategies
18. Various isolation and purification strategies
19. Methods for residual metal removal
20. Methods for impurity removal
21. Pharmaceutical salts
22. Solid form
About the author
Dr Wenyi Zhao, Senior Research Scientist (Process Chemistry), Member of American Chemical Society. 1980-1990: Ph.D., Organic/Physical Organic Chemistry, Nanjing University, China. 1990-1992: Postdoctoral fellow in Institute of Chemistry, Chinese Academy of Sciences, Beijing. 1992-1995: Associate professor in Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing (Now becomes Institute of Chemistry, Chinese Academy of Sciences, Beijing). 1995-2001: Sr. research associate in Department of Chemistry, Texas Tech University, Lubbock, Texas 2001 - 2005. Dr Wenyi Zhao then moved into the private sector to become a process chemist in the pharmaceutical industry in the US with over 15 years of experience. He is the author of numerous journal articles and holds several patents.
Summary
This handbook is designed to provide readers with an unprecedented strategy approach to mechanism-guided process development, helping process chemists and students in industrial chemistry develop chemical processes efficiently. The latest edition addresses common process issues such as safety, cost, robustness, and environmental impact.
