The Complete Spleen - Structure, Function, and Clinical Disorders

In this thoroughly revised and updated second edition, a panel of distinguished clinical researchers from around the world takes stock of the wealth of new knowledge about the human spleen and applies it to the pathology and treatment of splenic diseases. This much enriched understanding encompasses the spleen's complex role in immunological defense, the recently defined function of particulate filtration by the spleen, and the structural basis for the functions of the spleen, most particularly the microvasculature around which it is organized. Among the diseases and disorders of the spleen considered in detail are splenomegaly, the consequences and management of hyper- and hyposplenism, and 'dilutional anemia.' Recent advances in splenic surgery are also reviewed, especially those techniques intended to preserve at least partial function while removing the greater part of the organ.

List of contents

"I. The Structure and Function of the Spleen

The Anatomy of the Spleen
Ronald A. Bergman, Paul M. Heidger, Jr., and Carol E. H. Scott-Conner

The Microanatomy of the Mammalian Spleen: Mechanisms of Splenic Clearance
Fern Tablin, Jack K. Chamberlain, and Leon Weiss

Splenic Microcirculatory Blood Flow and Function with Respect to Red Blood Cells
Alan C. Groom, Ian C. MacDonald, and Eric E. Schmidt

The Immune Functions of the Spleen
Morris O. Dailey

The Role of the Spleen in Hemostasis
W. Jean Dodds

II. Characteristics of the Disordered Spleen

The Pathology of the Spleen
Mohammad A. Vasef and Charles E. Platz

Splenic Pooling and Survival of Blood Cells
Anthony J. Bowdler and Frank Gary Renshaw

Dilutional Anemia: Abnormalities of Blood Volume in Disorders of the Spleen
Anthony J. Bowdler and Frank Gary Renshaw

III. Clinical Aspects of Disorders of the Spleen

The Clinical Significance of the Spleen
Anthony J. Bowdler

Hyposplenism
Monty Seymour Losowsky and Peter Nigel Foster

The Relationship of the Spleen to Infection
Thomas C. Rushton, Geoffrey J. Gorse, and Anthony J. Bowdler

Hemolysis and Thrombocytopenia
David R. Anderson and John G. Kelton

Myeloproliferative Disorders
Michael T. Shaw

The Spleen in Lymphoproliferative Disease
Peter C. Raich

The Spleen in Sickle Cell Disease
Graham R. Serjeant

Imaging of Spleen Disorders
Mark R. Paley and Pablo R. Ros

Surgery of the Spleen
Carol E. H. Scott-Conner, Anne T. Mancino, and John Lawrence"

Summary

In this thoroughly revised and updated second edition, a panel of distinguished clinical researchers from around the world takes stock of the wealth of new knowledge about the human spleen and applies it to the pathology and treatment of splenic diseases. This much enriched understanding encompasses the spleen's complex role in immunological defense, the recently defined function of particulate filtration by the spleen, and the structural basis for the functions of the spleen, most particularly the microvasculature around which it is organized. Among the diseases and disorders of the spleen considered in detail are splenomegaly, the consequences and management of hyper- and hyposplenism, and "dilutional anemia." Recent advances in splenic surgery are also reviewed, especially those techniques intended to preserve at least partial function while removing the greater part of the organ.

Additional text

"There are detailed descriptions of the immune functions of the spleen as well as excellent photographs of the pathology of different splenic diseases. In the clinical aspects of the disorders of the spleen, there is a well thought out sequence of discussions about the various disorders and their ! clinical consequences. There are detailed CT scan images demonstrating different splenic disorders and excellent illustrations of the different surgical techniques on the spleen. . .This is an outstanding compendium of diseases related to the spleen. It gives the reader a complete and well-written view of this organ and its disorders. It is a well illustrated and a well thought out book. It provides the clinician with clear plans for treatment of various disorders, including surgical procedures, and provides the physician with up-to-date methods to diagnose particular splenic disorders. I found the surgical section to be particularly clear and well written. I would highly recommend this book to anyone with an interest in this organ. Although the spleen is a typically a mysterious organ to most of us, after reading this book, one will have a much better concept about its structure and function. "-Doody's Health Sciences Book Review Journal

"...This is an authoritive and inspirational book and would appeal to pathologists, microbiologists, surgeons and interested students." - European Journal of Haematology

Product details

• Assisted by: Anthony J. Bowdler (Editor), Anthon J Bowdler (Editor), Anthony J Bowdler (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2001
• EAN: 9780896035553
• ISBN: 978-0-89603-555-3
• No. of pages: 331
• Weight: 1250 g
• Illustrations: Illustr.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; B, Medicine, Gastroenterology, blood cell;cell;imaging;pathology;surgery