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In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called 'protease web', and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events.
List of contents
1. Proteolytic signalling: an introduction
André Zelanis, Uilla Barcick and Maurício F. Camacho
2. Ubiquitin-ligases: proteolytic signaling, protein turnover, and disease
Felipe Roberti Teixeira, Patricia Passos, Camila Correia, Caio Almeida, Valentine Spagnol and Isabela Fernanda Morales Martins
3. Lysosomal proteases and their role in signaling pathways
Rebecca A.B. Burton, Samuel Bose and Thamali Ayagama
4. Antigen processing and presentation through MHC molecules
Niels Olsen Saraiva Câmara, Tamisa Honda and Barbara Padovani
5. Proteolytic processing in autophagy
João Agostinho Machado-Neto and Andrei Leitão
6. Proteolysis in inflammatory diseases
Antoine Dufour and Luiz de Almeida
7. Proteolytic processing of laminin and the role of cryptides in tumoral biology
Vanessa Morais Freitas, Ruy Gastaldoni Jaeger and Adriane Sousa de Siqueira
8. Proteolytic signaling in wound healing
Ulrich auf dem Keller, Konstantinos Kalogeropoulos and Louise Bundgaard
9. Proteinases disbalance in oral cancer and other diseases
Adriana Franco Paes Leme
10. 'Omics' approaches for investigating protease degradomes in complex biological matrices
Pitter F. Huesgen and Maithreyan Kuppusamy
11. Protease web
Nikolaus Fortelny and Wolfgang Esser-Skala
12. The puzzle of proteolytic effects in hemorrhage induced by Viperidae snake venom metalloproteinases
Milene Menezes, Dilza Trevisan-Silva, Daniela Cajado De Oliveira Souza Carvalho and Jessica de Alcantara Ferreira
About the author
Dr. André Zelanis is Assistant professor of Proteomics and Systems Biology, and Head of the Functional Proteomics Laboratory at the Department of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil. His research focuses in proteomics and mass spectrometry-based approaches to uncover protease function in biological signaling pathways. Currently his lab is using proteomics to explore the repertoire of substrates (degradome) of proteases secreted by melanoma cells in culture and evaluating proteolytic processing events in the plasma of patients with metastatic melanoma. He has published widely in such peer reviewed journals as the Journal of Proteome Research and Comparative Biochemistry and Physiology.
