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This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue, for several types of cancers, e.g. glioblastoma stem cells. Recent developments have revealed completely different roles of distinct stem cells within the same organ.
Thus, Stem Cells Heterogeneity in Cancer provides a timely update us on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity - Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.
List of contents
Multilayered heterogeneity of glioblastoma stem cells: biological and clinical significance.- Heterogeneity of head and neck squamous cell carcinoma stem cells.- Heterogeneity of small cell lung cancer stem cells.- Heterogeneity of hepatic cancer stem cells.- Heterogeneity and plasticity of breast cancer stem cells.- Heterogeneity of melanoma with stem cell properties.- Heterogeneity of colon cancer stem cells.- Urothelial cancer stem cell heterogeneity.- Acute myeloid leukemia stem cell heterogeneity and its clinical relevance.- Contribution of chronic myeloid leukaemia (CML) as a disease model to define and study clonal heterogeneity.- The heterogeneity of osteosarcoma: the role played by cancer stem cells.- Ovarian cancer stem cell heterogeneity.- Index.
About the author
Alexander Birbrair received his Bachelor's Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette's laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC).
