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Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila's value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases.
The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
List of contents
Ch1 Drosophila as a model organism.-Ch2 Adult intestine aging model.-Ch3 Alzheimer's disease model.-Ch 4 Parkinson's disease model.-Ch 5 Repeat expansion disease model.-Ch 6 Amyotrophic lateral sclerosis model.-Ch7 Charcot-Marie-Tooth disease model.-Ch8 Role of long non-coding RNA in neurological diseases.-Ch9 Muscular dystrophy model.-Ch10 Cancer model.-Ch11 Leukemia model.-Ch12 Diseases of replication /repair genes.-Ch13 Drosophila models for studying UPR in insulin-like peptide producing cells and onset of type I diabetes.-Ch14 Metabolomics study on Drosophila models.-Ch15 Humanized flies for functional analysis of the human genome and cross-species comparison.-Ch16 Designs for Flies
About the author
Masamitsu Yamaguchi received his PhD from Osaka University and is currently a Professor of Applied Biology, Kyoto Institute of Technology. He is a former director of the Advanced Insect Research Promotion Center at Kyoto Institute of Technology.
Summary
Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases.
The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
