Genetics of Steroid Biosynthesis and Function

Steroids are among the most widely prescribed drugs for humans, and steroid signaling pathways are present in vertebrates, plants, insects and fungi, presenting new avenues for biotechnological intervention. Genetics of Steroid Biosynthesis and Function focuses on the genetic and cellular aspects of mammalian steroid hormones with particular attention to inherited gene lesions. With contributions from a panel of international experts, this volume provides an accessible, up-to-date overview of modern steroid biology for both the professional and novice researcher alike.

List of contents

Steroid Biosynthesis: Enzymology, Integration and Control. Sterol Biosynthesis. Vitamin D Biosynthesis and its Disorders. Bile Acid Biosynthesis. Cholesterol Metabolism in Steroidogenic Tissues. Steroid 21-Hydroxylase. Steroid 11ß-Hydroxylase Isozymes. 3ß-Hydroxysteroid Dehydrogenase/ Isomerase Deficiency. Human 17a-Hydroxylase/17, 20-Lyase. Aromatase: Insights into the Roles of Estrogens Revealed by Natural and Targeted Mutations. 17ß-Hydroxysteroid Dehydrogenase and 5a-Reductase Deficiencies. Steroid Metabolism in Peripheral Tissues. Animal Models of Impaired Steroidgenesis. Regulation of Gene Expression by the Nuclear Receptor Family. Neurosteroids and Brain Sterols.

About the author

J.I. Mason

Summary

This volume provides an accessible, up-to-date overview of modern steroid biology for both the professional and novice researcher alike.

Product details

• Assisted by: J. I. Mason (Editor), J.I. Mason (Editor), J.I. (University of Edinburgh Mason (Editor)
• Publisher: Taylor and Francis
• Languages: English
• Product format: Hardback
• Released: 31.12.2021
• EAN: 9780415278782
• ISBN: 978-0-415-27878-2
• No. of pages: 498
• Weight: 1115 g
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; SCIENCE / Life Sciences / General, MEDICAL / Biochemistry, SCIENCE / Life Sciences / Molecular Biology, SCIENCE / Life Sciences / Genetics & Genomics, biochemistry, molecular biology, Genetics (non-medical)