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Informationen zum Autor Ronald Pethig Emeritus Professor of Bioelectronics, The University of Edinburgh, UK Klappentext Dielectrophoresis: Theory, Methodology and Biological Applications describes the significant advances in the theory, technology and biomedical applications of dielectrophoresis since Herbert Pohl's seminal monograph of 1978. Taking an interdisciplinary approach, it covers aspects of the theory and practice of dielectrophoresis concerned with characterizing and manipulating cells and other bioparticles such as bacteria, viruses, proteins and nucleic acids. An introductory chapter places dielectrophoresis in context as a particle manipulator, and chapters are included to describe the dielectric properties of bioparticles and microfluidic concepts of relevance. Applications described include: Characterisation and Sorting of Stem Cells Separation of Cancer Cells from Blood Cell-based Drug Discovery Diagnostics Sensors for Biomedical Applications Environmental Monitoring This is a valuable resource for those studying bioelectronics, BIOMEMS, biophysics, biosensors, lab-on-chip technologies, microfluidics, particle analysis and separation, as well as for researchers working on the fundamentals of dielectrophoresis across a wide range of applications, both biological and non-biological. More formal and quantitative material is shown in text boxes for easy identification, while worked examples throughout the text assist student engagement with theory and practical modelling. Zusammenfassung Comprehensive coverage of the basic theoretical concepts and applications of dielectrophoresis from a world-renowned expert. Inhaltsverzeichnis Index of Worked Examples xi Preface xiii Nomenclature xvii 1 Placing Dielectrophoresis into Context as a Particle Manipulator 1 1.1 Introduction 1 1.2 Characteristics of Micro-Scale Physics 2 1.3 Microfluidic Manipulation and Separation of Particles 3 1.4 Candidate Forces for Microfluidic Applications 4 1.5 Combining Dielectrophoresis with other Forces 25 1.6 Summary 26 1.7 References 27 2 How does Dielectrophoresis Differ from Electrophoresis? 31 2.1 Introduction 31 2.2 Electric Field 32 2.3 Electrophoresis 33 2.4 Induced Surface Charge and Dipole Moment 38 2.5 Dielectrophoresis 40 2.6 Summary 46 2.7 References 47 3 Electric Charges, Fields, Fluxes and Induced Polarization 49 3.1 Introduction 49 3.2 Charges and Fields 50 3.3 Gauss's Law 61 3.4 Induced Dielectric Polarization 71 3.5 Capacitance 73 3.6 DivergenceTheorem and Charge Density Relaxation Time 74 3.7 Summary 75 3.8 References 76 4 Electrical Potential Energy and Electric Potential 77 4.1 Introduction 77 4.2 Electrical Potential Energy 77 4.3 Electrical Potential 81 4.4 Electrostatic Field Energy 87 4.5 Summary 89 4.6 References 91 5 Potential Gradient, Field and Field Gradient; Image Charges and Boundaries 93 5.1 Introduction 93 5.2 Potential Gradient and Electrical Field 93 5.3 Applying Laplace's Equation 96 5.4 Method of Image Charges 110 5.5 Electric Field Gradient 112 5.6 Electrical Conditions at Dielectric Boundaries 114 5.7 Summary 116 5.8 References 117 6 The Clausius-Mossotti Factor 119 6.1 Introduction 119 6.2 Development of the Clausius-Mossotti-Lorentz Relation 121 6.3 Refinements of the Clausius-Mossotti-Lorentz Relation 131 6.4 The Complex Clausius-Mossotti Factor 134 6.5 Summary 141 6.6 References 143 7 Dielectric Polarization 145 7.1 Introduction 145 7.2 Electrical Polarization at the Atomic and Molecular L...
