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Laryngotracheal Reconstruction: From Lab to Clinic lines for using the technique of tracheal autotra- presents the experimental and clinical aspects of plantation in conservation laryngectomy. The tissue reconstruction of the larynx and trachea. shortcomings and complications of tracheal auto- The book reflects the development and implemen- transplantation encountered in the initial patient tation of a research-based clinical program. The series led to a modification of the technique. The experimental work was started in 1989 with the modified autotransplantation technique proved to aim of improving the reconstructive possibilities be reliable from a reconstructive, functional and in the following two clinical situations: (1) extend- oncological viewpoint. ed hemilaryngectomy defects after tumour In a second part (Chap. VI), healing aspects after removal and (2) tracheal stenoses that are impos- repair of laryngotracheal defects are highlighted. sible to repair by segmental tracheal resection. The The healing mechanisms of the cartilage support, two problems differ in localization (larynx, tra- the mucosal lining and the blood supply were chea), etiology (oncology, traumatic), and treat- studied for each tissue component individually.
List of contents
I. Introduction.- II. Limits in laryngotracheal reconstruction.- III. Tracheal transplantation research.- IV. From bench to bedside: Implementing tracheal autotransplantation as organ saving procedure after extended hemilaryngectomy.- V. Modification of tracheal autotransplantation concept: Towards optimal reconstruction of extended hemilaryngectomy defects.- VI. From wound healing research to tracheal reconstruction with preformed, composite tissue.- VII. Other vascularized reconstructive tissue for laryngeal repair.- VIII. Progress in head and neck reconstruction: a historical overview based on blood supply of the reconstructive tissue.
