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Informationen zum Autor Gary A. Rosenberg, MD Chairman of Neurology Professor of Neurology, Neurosciences, Cell Biology and Physiology, and Mathematics and Statistics University of New Mexico Health Sciences Center Albuquerque, NM Klappentext This book, authored by Gary A. Rosenberg, an authority on the physiology of brain fluids and metabolism, combines the classic physiology that dates back to the beginning of the nineteenth century with the advances in molecular sciences, providing a strong framework for understanding the diseases that are commonly treated by neurologists. Zusammenfassung The molecular basis for the physiology of the brain has advanced enormously in the past twenty years with an influx of new information gleaned through technological developments in neuroimaging and molecular discoveries. Molecular Physiology and Metabolism of the Nervous System, authored by Gary A. Rosenberg, an authority on the physiology of brain fluids and metabolism, combines the classic physiology that dates back to the beginning of the nineteenth century with the advances in molecular sciences, providing a strong framework for understanding the diseases that are commonly treated by neurologists. Molecular Physiology and Metabolism of the Nervous System focuses on the current neuropathology and implications of cerebrospinal fluid diseases and diseases of the blood-brain barrier: how the two affect stroke, infection, brain tumors, and increased intracranial pressure. The book discusses the effects of blood flow in stroke and dementia, the disruption of the blood-brain barrier in neuroinflammation, and the dysfunction due to brain edema and increased intracranial pressure. Molecular Physiology and Metabolism of the Nervous System is necessary reading for neurologists, neuroscientists, and residents in neurology, neurosurgery, and psychiatry, giving them a strong grounding in physiology and metabolism that will aid them in diagnosis and treatment. Inhaltsverzeichnis Part I: Physiology of brain fluids and blood-brain barrier Chapter 1: Anatomy of Fluid Interfaces that Protect the Microenvironment 1.1. Historical perspective 1.2 Cerebral microenvironment 1.3. Development of the brain-fluid interfaces 1.3.1. Neural tube, ependymal cells and stem cells 1.3.2. Cilated ependymal cells and CSF movement 1.3.3. Choroid plexuses, arachnoid and capillaries 1.4. Extracellular Space and Extracellular Matrix 1.5. Brain-Fluid Interfaces 1.5.1. Anatomy of the cerebral blood vessels 1.5.2. Brain cells interfaces with CSF at ependymal and pia 1.6. Dura, arachnoid and pial layers 1.7. What are sources of energy? Chapter 2: Physiology of the Cerebrospinal and Interstitial Fluids 2.1. Introduction 2.2. Proteins in the CSF 2.3. CSF Pressure Reflects Venous Pressure in the Right Heart 2.4. Formation, Circulation and Absorption of CSF 2.4.1. Formation of CSF by choroid plexuses 2.4.2. Choroid plexus and disease biomarkers in CSF 2.4.3. Absorption of CSF at the arachnoid villi 2.5. Electrolyte balance in the CSF 2.6. Meninges and sites of masses and infection 2.7. Interstitial fluid 2.8. Lyphatic drainage 2.9. Water diffusion, bulk flow if ISH and diffusion tensor imaging 2.10. Neuropeptides and fluid homeostasis 2.11. Aquaporins and water transport in the CNS Chapter 3: Neurovascular Unit 3.1. Early experiments on blood-brain barrier 3.2. The Neurovascular unit and tight junction proteins 3.3. Integrins, selectins and endothelial cell adhesion 3.4. Astrocytes, pericytes and basal lamina 3.5. Movement of substances into and out of brain 3.6. Glucose and amino acid transport 3.7. Proteases and the neurovascular unit 3.8. Matrix metalloproteinases (MMPs) 3.9. A disintegrin and metalloproteinase (ADAM) 3.10. Barrier systems evolved to an...
