Fr. 318.00

Inhibitors of Molecular Chaperones As Therapeutic Agents

English · Hardback

3-5 weeks (title will be specially ordered)

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Klappentext This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. Zusammenfassung This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. Inhaltsverzeichnis Section I Structure and Function: Conformational Dynamics, Structure and Functional Interactions of Hsp90 Chaperones; Structural Basis of Hsp90 Function; Structure and Function of Hsp70 - TBD; Exploiting the Dependency of Cancer Cells on Molecular Chaperones; Section II Small Molecule Inhibitors; Discovery of BIIB028; Discovery of STA-9090; Discovery of Serenex Hsp90 Inhibitor; Discovery of NVP-AUY922; Discovery of NVP-HSP990; Inhibitors of Hsp90 C-Terminal Domain; Hsp70 Inhibitors; Section III Clinical Perspectives; Clinical Development of Hsp90 Inhibitors as Anti-Cancer Agents; Hsp90 as a Potential Anti-Malarial Agent; Biomarker Development and Indication Selection; Other Disease Indications

Product details

Authors Timothy D Gao Machajewski, Timothy D. Gao Machajewski
Assisted by Zhenhai Gao (Editor), Timothy D. Machajewski (Editor), David Rotella (Editor)
Publisher Royal Society Of Chemistry
 
Series RSC Drug Discovery
Subjects Natural sciences, medicine, IT, technology > Biology > Biochemistry, biophysics
Natural sciences, medicine, IT, technology > Medicine > Pharmacy
Languages English
Product format Hardback
Released 28.10.2013
 
EAN 9781849736664
ISBN 978-1-84973-666-4
No. of pages 442

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