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Gene therapy for inflammatory diseases is a new , burgeoning field ofmedicine. Edited by the undisputed pioneers of this area of research,this volume is the first devoted to its topic. It contains thirteenchapters, each written by leaders in their respective fields, thatsummarize the state of the art in developing novel, gene basedtreatments for inflammatory diseases. As well as providing anintroduction to the basic concepts of gene therapy and the use of nakedDNA approaches, the book describes the advances that have been made inapplying them to arthritis, lupus, multiple sclerosis, diabetes,Sjogren`s syndrome and transplantation.One chapter is devoted todiscussing the first human clinical trials that apply gene therapy tothe treatment of an inflammatory disease. As well as providing noveltherapeutic approaches, gene therapy facilitates the development of newand improved animal models of disease; a chapter describing theseadvances is also included. As an up-to-date, timely book written by th
List of contents
Gene therapy for inflammatory diseases - basic concepts.- Gene therapy for rheumatoid arthritis: preclinical studies.- Cartilage erosion in rheumatoid arthritis: studies in SCID mouse model.- Gene therapy for rheumatoid arthritis: clinical studies.- Cytokine gene therapy of allergic airways inflammation.- Gene therapy for inflammatory diseases of the salivary glands.- Gene therapy for management of lupus: correction of Fas and Fas ligand-induced apoptosis in murine disease - therapeutic rationale and strategies.- Gene therapy for multiple sclerosis.- Gene therapy for type I diabetes mellitus.- Gene transfer to facilitate transplantation.- DNA vaccination as an anti-inflammatory strategy.- Naked DNA as a gene delivery vehicle in inflammatory diseases.- Animal models of arthritis generated by gene transfer.
