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Informationen zum Autor Professor Dr. Markus Albrecht: Institut für Organische Chemie, RWTH Aachen, Germany Professor Albrecht was born in 1964 and studied Chemistry in Würzburg and Münster, spending time as a postdoctoral fellow in the laboratories of Professor Kenneth N. Raymond in Berkeley, and a habilitation at the Institute of Organic Chemistry of the University of Karlsruhe. Since 2002 he has been Professor of Organic Chemistry at the RWTH Aachen, where his main topics of investigation are the self-assembly, structure and property of helicates, and influencing peptide conformations by metal coordination. Dr. Galia Maayan: The Department of Chemistry, University of Florida, USA Dr Maayan was born in 1974 and studied Chemistry at Tel Aviv University and at The Weizmann Institute of Science, Israel. She is currently a postdoctoral research associate with Professor Michael D. Ward and Kent Kirshenbaum, in the Molecular Design Institute at New York University, investigating the interaction between biomimetic foldamers and metal ions. Klappentext Metallofoldamers are oligomers that fold into three-dimensional structures in a controlled manner upon coordination with metal ions. Molecules in this class have shown an impressive ability to form single-handed helical structures and other three-dimensional architectures. Several metallofoldamers have been applied as sensors due to their selective folding when binding to a specific metal ion, while others show promise for applications as responsive materials on the basis of their ability to fold and unfold upon changes in the oxidation state of the coordinated metal ion, and as novel catalysts.Metallofoldamers: From Helicates to Biomimetic Architectures describes the variety of interactions between oligomers and metal species, with a focus on non-natural synthetic molecules.Topics covered include:* the major classes of foldamers and their folding driving force* metalloproteins and metalloenzymes* helicates: self-assembly, structure and applications* abiotic metallo-DNA* metallo-PNA and iDNA* metallopeptides* interactions of biomimetic oligomers with metal ions* applications of metallofoldamers Zusammenfassung Metallofoldamers are oligomers that fold into three-dimensional structures in a controlled manner upon coordination with metal ions. Molecules in this class have shown an impressive ability to form single-handed helical structures and other three-dimensional architectures. Inhaltsverzeichnis List of Contributors xi Foreword xiii Preface xv 1 Metalloproteins and Metallopeptides - Natural Metallofoldamers 1 Vasiliki Lykourinou and Li-June Ming 1.1 Introduction 1 1.2 Metalloproteins 2 1.3 Metallopeptides 12 1.4 Conclusion and Perspectives 28 Acknowledgements 30 References 30 2 Introduction to Unnatural Foldamers 51 Claudia Tomasini and Nicola Castellucci 2.1 General Definition of Foldamers 51 2.2 Biotic Foldamers 53 2.3 Abiotic Foldamers 70 2.4 Organization Induced by External Agents 72 2.5 Applications 78 2.6 Conclusions and Outlook 81 References 81 3 Self-Assembly Principles of Helicates 91 Josef Hamacek 3.1 Introduction 91 3.2 Thermodynamic Considerations in Self-Assembly 93 3.3 Cooperativity in Self-Assembly 100 3.4 Kinetic Aspects of Multicomponent Organization 104 3.5 Understanding Self-Assembly Processes 108 3.6 Secondary Structure and Stabilizing Interactions 118 3.7 Conclusions 118 References 120 4 Structural Aspects of Helicates 125 Martin Berg and Arne L ü tzen 4.1 Introduction 125 4.2 Structural Dynamics 127 4.3 Template Effects 129 4.4 Sequence Selectivity 130 4.5 Self-Sorting Effects in...
