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Informationen zum Autor Young-Joon Surh is the editor of Nutrition and Physical Activity in Aging, Obesity, and Cancer: The Third International Conference, Volume 1271, published by Wiley. Yong Sang Song is the editor of Nutrition and Physical Activity in Aging, Obesity, and Cancer: The Third International Conference, Volume 1271, published by Wiley. Klappentext "Nutrition and Physical Activity in Aging, Obesity, and Cancer presents a series of short reviews probing the connections of physical and nutritional factors with health and disease. The work presented here gives special attention to the deleterious effects of metabolic dysregulation and obesity as potential mechanisms that amplify the development and proliferation of cancer. Notable inclusions in this volume are papers examining the molecular basis of inflammatory bowel disease, chemoresistance in ovarian cancer, and skin cancer; the interaction of obesity and inflammation in cancer risk; and proteomic signaling in the regulation of skeletal muscular health and metabolism."--Publisher's description. Zusammenfassung This Annals volume presents a series of short reviews stemming from the 2012 3rd International Conference on Nutrition and Physical Activity (NAPA) in Aging! Obesity! and Cancer. Inhaltsverzeichnis Cancer prevention as biomodulation: targeting the initiating stimulus and secondary adaptations 1 Priscilla A. Furth Janus-faced role of SIRT1 in tumorigenesis 10 Na-Young Song and Young-Joon Surh Unfolded protein response to autophagy as a promising druggable target for anticancer therapy 20 Dong Hoon Suh, Mi-Kyung Kim, Hee Seung Kim, Hyun Hoon Chung and Yong Sang Song Genomics of complex traits 33 James E. Womack, Hyun-Jin Jang, and Mi Ok Lee Obesity and cancer risk: evidence, mechanisms, and recommendations 37 Ivana Vucenik and Joseph P. Stains Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression 44 Hsiao-Chi Wang, Jung Pao, Shuw-Yuan Lin, and Lee-Yan Sheen Molecular function of macrophage migration inhibitory factor and a novel therapy for inflammatory bowel disease 53 Jun Nishihira Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum 58 Ahmed Y. Ali, Lee Farrand, Ji Young Kim, Sanguine Byun, Jeong-Yong Suh, Hyong Joo Lee and Benhamin K. Tsang Inositol polyphosphate multikinase signaling in the regulation of metabolism 68 Joo-Young Lee, Young-ran Kim, Jina Park, and Seyun Kim Cutaneous responses to environmental stressors 75 Giuseppe Valacchi, Claudia Sticozzi, Alessandra Pecorelli, Franco Cervellati, Carlo Cervellati, and Emanuela Maioli Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue 82 Stephen D. Hursting and Sarah M. Dunlap Select nutrients, progesterone, and interferon tau affect conceptus metabolism and development 88 Fuller W. Bazer, Jingyoung Kim, Gwonhwa Song, Hakhyun Ka, Carmen D. Tekwe, and Guoyao Wu Diversification and conservation of the extraembryonic tissues in mediating nutrient uptake during amniote development 97 Guojun Sheng and Ann C. Foley Genetic modification of chicken germ cells 104 Tae Sub Park and Jae Yong Han Role of PGC-1¿ signaling in skeletal muscle health and disease 110 Chounghun Kang and Li Li Ji MicroRNA-target interactions: new insights from genome-wide approaches 118 Dooyoung Lee and Chanseok Shin ...