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Although cell turnover in normal adult liver is extremely low, hepatic tissue is notorious for its almost infinite capacity to regenerate in cases of viral, toxic or traumatic damage. Hepatocellular carcinoma is one of the most frequent malignancies worldwide and causes more than a million deaths per year. The mechanisms governing normal proliferation and malignant transformation of liver cells are of utmost interest for the understanding of regeneration and hepatocarcinogenesis and for the development of new therapeutic strategies.
Therefore, the International Falk Workshop held in Halle, Germany, on January 29-30 1998, focused on the issues of normal and malignant liver cell growth. Knowledge in this area of research has expanded rapidly during recent years. This book of proceedings summarizes the latest advances both in basic science and clinical research. Stimulating discussion set the basis for the development of new strategies in diagnosis and treatment of hepatocellular carcinoma and for the manipulation of regeneration in cases of acute or chronic loss of functional liver tissue.
Inhaltsverzeichnis
Preface. Section I: Liver Growth and Repair. 1. Overview: Recent Developments in Liver Growth - New Pieces to the Puzzle; D.R. LaBreque. 2. Hepatocyte Growth Factor (HGF) and Liver Regeneration; G.K. Michalopoulos, et al. 3. A Diversity of EGF-Like Ligands and Receptors in Liver; W.E. Russell, R.S. Carver. 4. Cytokine Regulation of Liver Regeneration; A.M. Diehl. 5. Initiation of Liver Regeneration by Tumor Necrosis Factor; E.M. Webber, et al. 6. IL-6 and Liver Growth Regulation; R. Taub. 7. Mechanisms of Liver-Specific Gene Transcription During Liver Regeneration; C. Trautwein, et al. 8. Phenotypic Plasticity of Normal and Neoplastic Rat Liver Epithelial Stem-Like Cells: Implications for Identifying Liver Stem Cells in Vivo; J.W. Grisham, W.B. Coleman. 9. Fetal Hepatocytes Differentiate Along the Hepatocyte and Biliary Lineages Following Hepatic Transplantation; R.A. Faris, A.-H. Hammo. 10. Immunohistochemical Properties of Putative Human Hepatic Epithelial Stem Cells; H.A. Crosby, et al. Section II: Hepatocarcinogenesis and Hepatocellular Carcinoma. 11. Analysis of Genetic Events during Mouse Hepatocarcinogenesis in Transgenic Models; S.S. Thorgeirsson, et al. 12. The Role of Apoptosis in Hepatocarcinogenesis; R. Schultze-Hermann, et al. 13. Multifaceted M6P/IGF2R Liver Tumor Suppressor; R.L. Jirtle. 14. The Ductular Reaction in Liver Disease - Emphasis on a Type I Response; A.J. Demetris, et al. 15. Abrogation of Negative Growth Regulatory Pathways by Hepatitis B Virus Encoded X Antigen in the Development of Hepatocellular Carcinoma; M.A. Feitelson, et al. 16. Genetic and Functional Analysis of the Effects of Hepatitis B Viral Transactivator HBx on Cell Growth and Apoptosis: Implications for Viral Replication and Hepatocarcinogenesis; H. Sirma, et al. 17. Hepatitis C Virus and Hepatocellular Carcinoma; W.H. Caslemann. 18. Risk Factors for Hepatocellular Carcinoma in Cirrhosis; M. Borzio, M. Roncalli. 19. Interventional Treatment of Hepatocellular Carcinoma; M. Beaugrand, et al. 20. Liver Transplantation vs Liver Resection for Hepatocellular Carcinoma; P.E. Majno, et al. 21. Gene Therapy for Hepatocellular Carcinoma: Concepts and Perspectives; H.E. Blum, et al. Index.
