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This book introduces the emerging field of chemical biology of carbohydrates, presenting significant advances in the study of carbohydrate chemistry and biology. Leading experts in Japan provide comprehensive explanations of their research, integrating both chemical and biological perspectives. The volume highlights research strategies, experimental approaches, and the challenges encountered in this interdisciplinary field, offering readers insight into the development of scientific ideas and methodologies. Although focused on Japanese research, the content is relevant to an international audience. Designed for graduate students, researchers, and educators, this book provides authoritative, up-to-date knowledge and serves as a valuable resource for teaching, research guidance, and exploring new directions in carbohydrate chemistry and biology.
Inhaltsverzeichnis
Precise Synthesis and Structure-Activity Relationship Studies of Low-Molecular-Weight Fucoidan Analogues.- Chemical approach to uncover the biological functions of sialic acid-containing glycans.- Synthetic strategies for di-, oligo-, and polysialic acids with applications as Siglec ligands.- Chemical Biology of Core M3 O-Mannosyl Glycan.- Chemical Approaches to Understand Physiological Functions of High-Mannose-Type Glycan-Related Proteins.- Pseudo-Glycans as Molecular Tools for Chemical Glycobiology.- Elucidating the Immune Functions of Glycans through Synthesis-Based Approaches.-Chemical Approaches to Explore the Function of Bacterial Glycolipid MPIase.-Glycolipid-recognizing C-Type lectin receptors: ligand structures and molecular probes for biofunctional analysis.-Multivalent Probes for Exploring Carbohydrate Binding Proteins..
Über den Autor / die Autorin
Kazunobu Toshima received Ph.D. degree in 1988 from Keio University under the direction of Professors Mitsuhiro Kinoshita and Kuniaki Tatsuta. He spent one year in Professor K. C. Nicolaou’s group at the University of Pennsylvania as a postdoctoral fellow. He was appointed as Lecturer of the Department of Applied Chemistry at Keio University in 1989. He was promoted to Assistant Professor in 1994, Associate Professor in 1996, and Full Professor in 2003 at Keio University. He was awarded The Chemical Society of Japan Award for Young Chemists in 1995, Taro Yamashita Academic Award in 1996, The Chemical Society of Japan Award for Creative Work in 2014, and SSOCJ Daiichi-Sankyo Award for Medicinal Organic Chemistry in 2015.
Yukari Fujimoto is Professor in Department of Chemistry, Keio University. She received her B.S. from Osaka University in 1989. After gaining industrial experience at Sumitomo Chemical Co., Ltd. and post-graduate studies at Columbia University, USA (Prof. Koji Nakanishi), she received her Ph.D. from Osaka University in 2002. After postdoctoral studies at Nagoya University, she joined the faculty of Osaka University as Assistant Professor in 2003 (Profs. Shoichi Kusumoto, and Koichi Fukase), where she promoted to Lecturer (2006) and to Associate Professor (2008). In 2014, she moved to Keio University as a Full Professor. She received several awards, including the Shionogi Award in Synthetic Organic Chemistry in 2021, the Alois Nowotny Award from International Endotoxin Society in 2012 and SSOCJ Incentive Award in Synthetic Organic Chemistry in 2007.
Zusammenfassung
This book introduces the emerging field of chemical biology of carbohydrates, presenting significant advances in the study of carbohydrate chemistry and biology. Leading experts in Japan provide comprehensive explanations of their research, integrating both chemical and biological perspectives. The volume highlights research strategies, experimental approaches, and the challenges encountered in this interdisciplinary field, offering readers insight into the development of scientific ideas and methodologies. Although focused on Japanese research, the content is relevant to an international audience. Designed for graduate students, researchers, and educators, this book provides authoritative, up-to-date knowledge and serves as a valuable resource for teaching, research guidance, and exploring new directions in carbohydrate chemistry and biology.
