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Informationen zum Autor Sankar Ghosh Klappentext The transcription factor NF-kB plays a critical role in human health and disease by influencing diverse cellular processes! including immunity and cell survival. Such a broad role has led to studies by researchers from a variety of disciplines. The Handbook of Transcription Factor NF-kappaB brings these studies into a single convenient reference designed to inform researchers and students about the basic mechanisms of NF-kB signaling and function. It also presents cutting-edge research on its more specialized roles across different biological systems and diseases. Edited by a pioneer in the field! it features authoritative contributions from top researchers worldwide. Zusammenfassung Introduces readers to the complexities of the NF-kB system. This work explains how a multitude of extracellular and intercellular signals integrated at the level of this transcription factor have led to fundamental insights about many aspects of gene regulation and signal transduction. Inhaltsverzeichnis The NF-kB Pathway: A Paradigm for Inducible Gene Expression! S. Ghosh Structural Aspects of NF-kB and I?B Proteins! A. K. Moorthy! T. Huxford! and G. Ghosh Regulation of IKK! H. Häcker and M. Karin Control of NF-kB Activation by Ubiquitination! S. C. Ley and Y. Ben-Neriah Regulation of Nuclear NF-kB Action: A Key Role for Posttranslational Modification! L.F. Chen and W. C. Greene NF-kB in the Innate Immune System! M. S. Hayden and S. Ghosh NF-kB in the Adaptive Immune System: Lymphocyte Survival and Function! M. S. Hayden and S. Ghosh NF-kB and IKK as Key Mediators of Inflammation and Oncogenic Progression! A. S. Baldwin NF-kB and Associated Human Genetic Pathologies! A. Israël Regulating the Master Regulator NF-kB: From Natural Strategies to Rationally Designed Superdrugs! S. Withoff! V. Tergaonkar! and I. M. Verma Index
